Lab Test

Test Definition Number : 160
Test Definition Name : Gene sequencing panel (51-100 genes)
Lab Name : CID, Massachusetts General Hospital
Lab Test Number of THIS Version : 1158
Lab Test Name : Solid Fusion Assay
Status : Active
Expired : No
Updated : 2017-11-20 11:18 EST

General Attributes

Chromosome Band :
HUGO Gene Name :
ICD-Oncology Code
(includes WHO classification diagnoses)
:

Infectious Disease Attributes

Agent Category :
Non-virus Genus and Species :
Virus Family, Genus, and Species :

Lab-specific Attributes

Method : Sequencing - Next Generation (Massively Parallel) (NGS)
Specimen Source
(for clinical patient care these sources must be validated)
: Solid Tissue Paraffin-Embedded Formalin-Fixed
ICD-10 Code :
Use : Clinical - CLIA-certified lab
Research
Genetics Category : Acquired (somatic)
SNOMED CT :
LOINC :
Comments : TARGETS (EXONS) VALIDATED FOR CLINICAL REPORTING: ALK (19-22, intron 19), EGFR (2-7 exon skipping/vIII variant, 7-9, 16, 20, 24, 25), EWSR1 (4-14), FGFR2 (2, 8-10, 17), MET (exon 14 skipping), NUTM1 (3), RET (8-13), and ROS1 (31-37). ADDITIONAL TARGETED GENES (EXONS): AKT3 (1-3), ARHGAP26 (2, 10-12), AXL (19,20), BRAF (7-12, 15), BRD3 (9-12), BRD4 (10, 11), ERG (2-11), ESR1 (3-6), ETV1 (3-13), ETV4 (2, 4-10), ETV5 (2, 3, 7-9), ETV6 (1-7), FGFR1 (2, 8-10, 17), FGFR3 (8-10, 17, intron 17), FGR (2), INSR (12-22), JAZF1 (2-4), MAML2 (2, 3), MAST1 (7-9, 18-21), MAST2 (2, 3, 5, 6), MET (13, 15), MSMB (2-4), MUSK (7-9, 11-14), MYB (7-9, 11-16), NOTCH1 (2, 4, 26-31, internal exon 3-27 deletion), NOTCH2 (5-7, 26-28), NRG1 (1-3, 6), NTRK1 (8,10-13), NTRK2 (11-17), NTRK3 (13-16), NUMBL (3), PDGFRA (7, exon 8 deletion, 10-14), PDGFRB (8-14), PIK3CA (2), PKN1 (10-13), PPARG (1-3), PRKCA (4-6), PRKCB (3), RAF1 (4-7, 9-12), RELA (3, 4), RSPO2 (1, 2), RSPO3 (2), TERT (2), TFE3 (2-8), TFEB (1,2), THADA (28), and TMPRSS2 (1-6).
Specimen Transport Requirements : See http://www.massgeneral.org/pathology/CID
Samples Available for Proficiency Test Sample Exchange : No

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