Lab Test

Test Definition Number : 230
Test Definition Name : UGT1A1 sequence analysis
Lab Name : Mayo Clinic Personalized Genomics Laboratory
Lab Test Number of THIS Version : 1230
Lab Test Name : UGT1A1 TA Repeat Genotype
Status : Active
Expired : No
Updated : 2018-05-16 20:56 EDT

General Attributes

Chromosome Band : 2q37.1
HUGO Gene Name : [UGT1A1] UDP glucuronosyltransferase 1 family, polypeptide A1
ICD-Oncology Code
(includes WHO classification diagnoses)
:

Infectious Disease Attributes

Agent Category :
Non-virus Genus and Species :
Virus Family, Genus, and Species :

Lab-specific Attributes

Method : Polymerase Chain Reaction (PCR) - Real Time
Specimen Source
(for clinical patient care these sources must be validated)
: Blood - Whole Blood
Saliva
ICD-10 Code :
Use : Clinical - CLIA-certified lab
Clinical - certified for NY patients
Genetics Category : Pharmacogenetics
SNOMED CT :
LOINC :
Comments : HUGO Gene Name: UGT1A1 See https://www.mayomedicallaboratories.com/test-catalog/Overview/97400 Useful For: -Identifying individuals who are at increased risk of adverse drug reactions with drugs that are metabolized by UGT1A1; especially irinotecan, but also including atazanavir, nilotinib, pazopanib, and belinostat -Identifying individuals with Gilbert syndrome due to the presence of homozygous UGT1A1*6 (c.211G->A) allele, TA7, TA8, or compound heterozygous *6, TA7 or TA8 -Identifying individuals who are carriers of Gilbert syndrome due to the presence of heterozygous TA7 or TA8 This test only includes the TA repeat region within the promoter and the c.211G>A variant that defines the *6 allele. A UGT1A1 full gene sequencing test (UGTFG) is also available to interrogate the remainder of this gene.
Specimen Transport Requirements :
Samples Available for Proficiency Test Sample Exchange : No

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