Lab Test

Test Definition Number : 230
Test Definition Name : UGT1A1 sequence analysis
Lab Name : Mayo Clinic Personalized Genomics Laboratory
Lab Test Number of THIS Version : 1231
Lab Test Name : UGT1A1 Full Gene Sequencing
Status : Active
Expired : No
Updated : 2018-05-16 20:56 EDT

General Attributes

Chromosome Band : 2q37.1
HUGO Gene Name : [UGT1A1] UDP glucuronosyltransferase 1 family, polypeptide A1
ICD-Oncology Code
(includes WHO classification diagnoses)

Infectious Disease Attributes

Agent Category :
Non-virus Genus and Species :
Virus Family, Genus, and Species :

Lab-specific Attributes

Method : Sequencing - Sanger - Bi-directional
Specimen Source
(for clinical patient care these sources must be validated)
: Blood - Whole Blood
ICD-10 Code :
Use : Clinical - CLIA-certified lab
Clinical - certified for NY patients
Genetics Category : Germline (inherited)
Comments : HUGO Gene Name: UGT1A1 See Useful For: -Identifying individuals who are at increased risk of adverse drug reactions with drugs that are metabolized by UGT1A1, including irinotecan, atazanavir, nilotinib, pazopanib, and belinostat -Identifying individuals who are at risk of hyperbilirubinemia -Follow-up testing for individuals with a suspected UGT1A1 variant, who had negative TA repeat region testing -Establishing a diagnosis of Gilbert syndrome or Crigler-Najjar syndrome type I or type II -Establishing carrier status for Crigler-Najjar syndrome type I or type II This test is the full gene sequencing assay. If assessment of only the TA repeat region within the promoter and the *6 variant is desired, the UGT1A1 TA Repeat Genotype (U1A1V) test is also available.
Specimen Transport Requirements :
Samples Available for Proficiency Test Sample Exchange : No


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