Lab Test

Test Definition Number : 22
Test Definition Name : T-cell receptor gamma chain rearrangements
Lab Name : OHSU Knight Diagnostics Lab
Lab Test Number of THIS Version : 1241
Lab Test Name : T-Cell Gene Receptor (TCR) Gene Rearrangement
Status : Active
Expired : No
Updated : 2018-05-04 09:26 EDT

General Attributes

Chromosome Band : 7p14.1
HUGO Gene Name : [TRG] T cell receptor gamma locus
ICD-Oncology Code
(includes WHO classification diagnoses)
: [9702/3] Mature T-cell lymphoma, NOS
[9705/3] Angioimmunoblastic T-cell lymphoma
[9708/3] Subcutaneous panniculitis-like T-cell lymphoma
[9709/3] Cutaneous T-cell lymphoma, NOS
[9717/3] Intestinal T-cell lymphoma
[9719/3] NK/T-cell lymphoma, nasal and nasal-type
[9801/3] Acute leukemia, NOS
[9805/3] Acute biphenotypic leukemia
[9820/3] Lymphoid leukemia, NOS
[9827/3] Adult T-cell leukemia/lymphoma (HTLV-1 pos.)
[9831/1] T-cell large granular lymphocytic leukemia
[9831/3] T-cell large granular lymphocytic leukemia
[9837/3] T lymphoblastic leukemia/lymphoma

Infectious Disease Attributes

Agent Category :
Non-virus Genus and Species :
Virus Family, Genus, and Species :

Lab-specific Attributes

Method : Polymerase Chain Reaction (PCR) - Real Time
Specimen Source
(for clinical patient care these sources must be validated)
: Blood - Whole Blood
Bone Marrow Aspirate
ICD-10 Code :
Use : Clinical - CLIA-certified lab
Genetics Category : Acquired (somatic)
Comments : T-cell lymphomas account for approximately 15% of non-Hodgkin lymphomas and may pose a diagnostic challenge on the basis of histopathology alone and particularly in early stages of disease. The heterodimeric T-cell surface receptors, either alpha/beta (90% -95% of T cells) or gamma/delta (5% - 10% of T cells) are produced following somatic rearrangement of the T-cell receptor (TCR) genes (alpha, beta, delta, and gamma). This process is vital to proliferation of T-cells in normal immune function, but can be exploited to aid in the distinction between reactive (benign) versus neoplastic processes of T-cell proliferation. A reactive, benign T-cell proliferation is characterized by polyclonal expansion of T-cells whereas a malignant process is characterized by clonal expansion of one T-cell population. In conjunction with morphologic evaluation of lymph nodes, bone marrow and other tissue types the detection of a clonal T-cell gene rearrangement by polymerase chain reaction (PCR) can be used to aid a diagnosis of malignant T-cell lymphoma.
Specimen Transport Requirements : 5-10mL Blood or Bone Marrow (ACD or EDTA) Package and ship specimens to remain cold, but not frozen. Ship via overnight express. Contact Client Services at (855) 535-1522 for shipping kits and instructions.
Samples Available for Proficiency Test Sample Exchange : Yes


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